AIBioTech provides drug discovery and diagnostic development organizations a broad range of world-class laboratory services to bring new products to market. Led by Bill Miller, CEO, Robert B. Harris, PhD, President and CSO, and Thomas Reynolds, Executive Vice President, AIBioTech is one of the world's most comprehensive Contract Research Organizations in operation. AIBioTech provides reliable expertise and cutting-edge technologies which are not available from other companies.
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Sildenafil, tadalafil, and vardenafil, are potent inhibitors of cGMP dependent-phosphodiesterase Type 5 (“PDE-5”), and are the active ingredients in Viagra™, Cialis™, and Levitra™, respectively. The primary indication for these compounds is treatment of erectile dysfunction, and these prescription drugs are now standard treatment for erectile dysfunction in all settings, including diabetes.
Recreational use of the PDE-5 inhibitors is increasing, based mainly on the belief that these drugs increase libido and improve sexual performance. Even though the many possible adverse side-effects from over-use or misdirected use of these compounds is well documented, the compounds are often used in combination with other stimulants or opiates in formulations dubbed “sextasy”, “rockin and rollin”, trail mix”, “herbal viagra”, or simply “male enhancement products.”
AIBioTech has now implemented an LC/MSMS assay which will reveal the presence and/or the relative concentrations of these compounds in male enhancement products. The test can be done using as little as 2 mg of sample, with limits of detection of the reference standards in the 50 picogram range. Order forms are available from the AI BioTech web site; email info@aibiotech.com, or call 1-800-735-9224 for more information.
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